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Several studies, including a randomized controlled trial from the Netherlands (JW Gastroenterol Jan 6 2012), have now reported the performance of laxative-free computed tomographic colonography (CTC). In the current industry-supported, prospective study, investigators evaluate the performance of laxative-free CTC followed by colonoscopy in 605 adults aged 50 to 85 undergoing screening or surveillance exams. As usual, the CTC was performed after several doses of contrast ingestion, and colonoscopy was performed blinded to the results of the CTC.
Per-patient sensitivity and specificity of laxative-free CTC for polyps ≥10 mm in size were 91% and 85%, respectively. Sensitivity fell dramatically for lower size thresholds. For adenomas ≥8 mm, the …