Five-Day, Levofloxacin-Based Concomitant Therapy for Helicobacter pylori

This regimen was as effective as 10-day sequential treatment in eradicating H. pylori infection and slightly less expensive.

Resistance to antibiotic drugs, particularly clarithromycin, is a major limitation in the treatment of Helicobacter pylori infection in some geographic regions. Consensus guidelines have suggested bismuth-based therapy in such regions (Gut 2007; 56:772), but that approach is often poorly tolerated by patients.

To compare the efficacy of two nonbismuth treatment regimens in eradicating H. pylori infection in a region with high clarithromycin resistance, investigators conducted a randomized, controlled, noninferiority trial involving 180 treatment-naive patients with H. pylori infection from two hospitals in Italy. Participants received a 5-day concomitant regimen of esomeprazole (40 mg), amoxicillin (1 g), levofloxacin (500 mg), and tinidazol…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose