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Prior randomized, controlled trials have established the benefits of chromoendoscopy and targeted biopsies for the detection of dysplasia (e.g., Gastroenterology 2003; 124:880), and both British and U.S. guidelines have endorsed chromoendoscopy as an alternative to obtaining random quadrantic biopsies with white-light endoscopy (WLE). Electronic chromoendoscopy using narrow-band imaging (NBI) offers an alternative that is faster and easier than dye-spraying, but two recent trials have shown that NBI does not improve dysplasia detection when compared with standard WLE (Endoscopy 2007; 39:216) or high-definition WLE (Endoscopy 2011; 43:108).
To further compare NBI versus high-definition WLE, investigators in the U.K. conducted a multicenter, r…