Obesity and Colorectal Adenomas Go Together

Numerous studies have identified obesity, diabetes mellitus, and metabolic syndrome as risk factors for colorectal adenomas, but none to date has quantified the association between body-mass index (BMI) and prevalence of colorectal adenomas.

In a meta-analysis of 23 studies involving 105,190 participants, patients with BMI ≥25 had a higher prevalence of colorectal adenoma than those with BMI <25 (odds ratio, 1.24; P<0.01). Multivariate analysis demonstrated a dose-response relationship between BMI and prevalence of colorectal adenoma.