Fluticasone Achieves Histologic Response in Eosinophilic Esophagitis

In a small, randomized trial of adults with EoE, the topical steroid was superior to placebo in reducing mean eosinophil count, but not symptoms.

Despite the rising incidence of eosinophilic esophagitis (EoE) in both adults and children, optimal strategies for both medical therapy and esophageal dilation are not yet identified (JW Gastroenterol Sep 3 2010). The efficacy of topical steroids (e.g., fluticasone, budesonide), systemic steroids, and proton-pump inhibitors have been described, even in patients without demonstrable gastroesophageal reflux disease (GERD) (JW Gastroenterol Jan 28 2011 and JW Gastroenterol Aug 12 2011), but only one randomized trial has been conducted and involved children only (JW Gastroenterol Mar 2 2007).

Now, investigators have tested the efficacy of fluticasone in reducing symptomatic dysphagia and histologic response in a double-blind, randomized trial in…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors