Long-Term PPI Use Does Not Accelerate Loss of Bone Mineral Density

Proton-pump inhibitor users had lower bone mineral density values than nonusers at study entry, but there was no difference in bone mineral density changes during the next 10 years.

Large case-control studies have suggested a possible relationship between the use of proton-pump inhibitors (PPIs) and an increase in osteoporosis and fractures. However, the strength of this association varies among studies (JW Gastroenterol Jul 30 2010).

Investigators in Canada suggest that demonstrating a link between PPI use and a loss of bone mineral density (BMD) would support the idea that PPIs increase risk for fracture. To identify this possible link, the researchers assessed prospectively collected data from the Canadian Multicentre Osteoporosis Study, which involved a population-based sample of patients who provided medical and medication history and underwent BMD testing of the lumbar spine, femoral neck, and total hip at the beg…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

Long-Term PPI Use Does Not Accelerate Loss of Bone Mineral Density

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Reviewing Author