Does H. pylori Affect Ulcer Bleeding in Aspirin Users?

Incidence of peptic ulcer rebleeding is low after Helicobacter pylori eradication, but high in patients with no history of infection.

Low-dose aspirin (ASA) and Helicobacter pylori infection can cause peptic ulcer bleeding (PUB) by different mechanisms. But is the incidence of PUB in ASA users affected by presence of H. pylori?

To find out, investigators in Hong Kong prospectively followed three cohorts of ASA users every 3 to 6 months for up to 10 years:

249 patients with healed peptic ulcers and eradicated H. pylori infection (HP eradicated)
118 patients with healed peptic ulcers and no history of H. pylori infection (HP negative)
537 patients with no history of PUB or H. pylori infection (average risk)

After 5048 patient-years of follow-up, the incidence of PUB per 100 patient-years was 0.97 (95% confidence interval, 0.53–1.80) in the HP-eradicated group; 5.22 (95% CI, 3.04…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

Does H. pylori Affect Ulcer Bleeding in Aspirin Users?

Topics

Reviewing Author