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Despite cure rates of >90% shown in studies of fecal microbiota transplantation for Clostridium difficile infection (JW Gastroenterol Mar 30 2012), no randomized controlled trials have yet been conducted, and published meta-analyses have methodological limitations. The current systematic review and meta-analysis assessed current evidence of efficacy for fecal microbiota transplantation in C. difficile infection.
Researchers identified 11 studies with a total of 273 patients in whom fecal microbiota transplantation was performed. Delivery methods varied: Colonoscopy was used exclusively in five studies, nasogastric or nasojejunal tube was used in three studies, and enema was used in one. Colonoscopy, gastroscopy, or gastrostomy tube was used …