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In the 1980s, researchers noted that the parkinsonism-causing toxicant MPTP shares structural and functional characteristics with pesticides. This observation prompted the proposal that pesticide exposure is a risk factor for Parkinson disease (PD). Despite numerous studies, an etiologic association remains controversial.
In this study, researchers addressed the concern that systematic bias (i.e., recall and selection bias) in prior cross-sectional studies might explain the association of pesticides with PD. The investigators conducted a follow-up study in more than 140,000 participants in the Cancer Prevention Study Nutrition Cohort. Participants responded to a survey in 1982 on occupations and chemical exposures (including pesticide and he…