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Most of the known paraneoplastic neurologic syndromes are devastating conditions for which diagnosis is important but treatments are limited, and the pathophysiologic mechanisms remain unclear. Researchers now report altering this situation dramatically for 12 young women (age range, 14–44) whose clinical presentations consisted of early psychiatric features followed by seizures, autonomic instability, and extrapyramidal manifestations and who were then recognized to harbor a teratoma.
Mild T2/FLAIR hyperintensity was present in the hippocampal formations or in other cerebral cortical structures in several cases. Hippocampal neuronal membranes were found to be the target of autoantibodies found in serum and in CSF. In 11 of the 12 patients, …