APOE Genotype and MRI Markers of Small Vessel Disease

Among ischemic stroke survivors, APOE ε2 carriers had a higher rate of white matter hyperintensities, but not microbleeds, than noncarriers.

Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage in elders and is associated with a high prevalence of markers of small-vessel disease, including white matter hyperintensities (WMH) and cerebral microbleeds. The apolipoprotein E (APOE) ε2 and ε4 alleles have been associated with CAA-related lobar intracerebral hemorrhage. In the current study, the authors sought to define the associations between these MRI markers and APOE genotype in a cohort of 342 patients with ischemic stroke or TIA who were recruited from an ongoing prospective cohort study.

The researchers semiquantitatively assessed the amount of WMH and recorded the number of microbleeds in each patient. The number of bleeds was highly correlated w…

Reviewing Author

Anand Viswanathan, MD, PhD

APOE Genotype and MRI Markers of Small Vessel Disease

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Reviewing Author