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On the French Caribbean island Guadeloupe, atypical parkinsonism is relatively common. Two forms have been reported, one resembling progressive supranuclear palsy (Gd-PSP) and one deemed an “unclassifiable” parkinsonism-dementia complex (Gd-PDC). To further characterize these syndromes, Lannuzel and colleagues used clinical, neuroimaging, and neuropsychological analyses to phenotype 104 individuals with atypical parkinsonism and compare them with 50 individuals with Parkinson disease (PD).
Half of the patients with atypical parkinsonism had Gd-PSP and half had Gd-PDC. Surprisingly, detailed examination did not support the clinical differentiation between the two subgroups, but instead uncovered common traits: levodopa-unresponsive parkinsoni…