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The C46T polymorphism of factor XII has been associated with decreased levels of factor XII (Thromb Res 2001; 101:255), and clinical evidence suggests that deficiencies may be associated with heightened risk for venous thrombosis. However, this factor activates both thrombosis and fibrinolysis, and deficiencies have also been associated with protection from acute coronary syndrome (J Thromb Haemost 2007; 5:700 and Br J Haematol 2001; 115:1007). In this case-control study, the authors investigated the association between the factor XII C46T polymorphism and cerebral venous thrombosis (CVT). They compared the prevalences of the TT polymorphism of C46T among 78 patients with CVT and among 201 healthy controls from South Germany.
The TT genotype…