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No consensus exists on how to classify and treat patients in whom the pattern of muscle weakness suggests inclusion body myositis (IBM) but whose biopsy findings would lead to classification as polymyositis (PM). To clarify this issue, these authors examined the associations among clinical features, muscle biopsy findings, and treatment responses in a retrospectively examined cohort of 107 patients in whom muscle biopsy indicated either PM or IBM. All 64 patients with IBM had selective finger flexor or quadriceps weakness (most had both). Of the 43 patients with biopsy findings typical of PM, the authors identified 16 who had the distribution of weakness of IBM, whose disease they therefore classified as PM/IBM.
The most important finding wa…