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Left cardiac sympathetic denervation has been shown to reduce release of norepinephrine in the myocardium. These researchers sought to determine whether this treatment would prevent potentially fatal exercise-induced catecholaminergic polymorphic ventricular tachycardia in patients for whom more conventional therapies had failed. They studied three subjects, two male and one female, who had mutations of the ryanodine 2 receptor. Each subject had exercise-induced arrhythmias prior to surgery.
After surgery, all three subjects were asymptomatic and had a reduced incidence of arrhythmias. Arrhythmias that did occur were induced only at much higher workloads than preoperatively. The authors conclude that left cardiac sympathetic denervation may …