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In these two studies, researchers tested mycophenolate mofetil (MM) for the treatment of myasthenia gravis (MG).
The Muscle Study Group performed a randomized, double-blind, partially manufacturer-supported trial of MM versus placebo for 12 weeks in 80 patients with mild-to-moderate generalized MG who were not currently receiving any form of immunotherapy. All subjects also received 20 mg of prednisone daily. The primary measure of efficacy was the change in the quantitative MG score from baseline to week 12. In both groups, quantitative MG scores improved similarly. During a 24-week open-label extension phase, the dosage of prednisone was reduced by similar amounts in the two groups.
Sanders and colleagues performed an international, multice…