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This consensus statement stemmed from the Health Outcomes in Pregnancy and Epilepsy (HOPE) forum, an international conference organized to summarize current information on issues regarding pregnancy in women with epilepsy (WWE) and identify areas for future research.
The major established pregnancy registries include the European and International Registry of Antiepileptic Drugs in Pregnancy (EURAP) and the North American (NA), United Kingdom (U.K.), and Australian registries. The registries have shown slightly different risks for malformations with specific antiepileptic drugs (AEDs), probably because of differences in patient populations and recruitment. Despite these differences, valproate, whether as monotherapy or polytherapy, is consis…