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Multitudinous connections link the chemosensory system and headaches, including connections between olfaction and migraine. People with migraine can experience osmophobia or olfactory-triggered migraine, hyposmia, cacosmia, and odor hyperresponsiveness or hypersensitivity. However, objective documentation of the subjective complaint of olfactory hypersensitivity has not hitherto existed. To provide such documentation, these authors used functional PET imaging before and during exposure to one of three sets of 20 odor combinations, in 11 patients with olfactory hypersensitivity and migraine in the interictal period and in 12 healthy controls.
During both exposure and nonexposure, the migraine group displayed greater cerebral blood flow in the…