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The diagnosis of restless legs syndrome (RLS) is made by subjective interview. An autosomal dominant pattern of inheritance is often found in cases with no identified secondary cause such as pregnancy, iron deficiency, renal failure, or peripheral neuropathy. Although RLS is associated with periodic limb movements that can be identified with polysomnography, no definitive objective marker for the disorder exists. Recently, two susceptibility genes have been identified — MEIS1 and BTBD9 — and five loci associated with RLS have been reported. Given the high prevalence of the condition and the syndromic nature of the diagnosis, there are likely to be multiple genetic contributors.
To provide additional data on the genetics of RLS, researchers e…