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To investigate gamma-knife radiosurgery as a noninvasive alternative to anterior temporal lobectomy for medically refractory mesial temporal lobe epilepsy, researchers conducted a multicenter, prospective study. They randomized 30 patients to either low-dose (20 Gy) or high-dose (24 Gy) radiosurgery and examined postsurgical seizure control, adverse events, and verbal memory.
Three years after treatment, 67.0% of the patients were seizure-free during the prior 12 months (76.9% of the high-dose and 58.8% of the low-dose groups). One patient experienced edema and visual impairment that did not respond to steroids and required temporal lobectomy. New, clinically significant headaches occurred in 85% of the high-dose and 58% of the low-dose grou…