Loading...
Small placebo-controlled studies of high-flow oxygen in the treatment of cluster headache have suggested significant efficacy, but the treatment's efficacy has not been confirmed in a high-quality trial. Now, researchers have conducted a larger, partially manufacturer-sponsored, randomized, placebo-controlled, crossover trial of home use of high-flow oxygen delivered via mask. The authors randomized 109 adults with episodic or chronic cluster headache, previously naive to oxygen therapy, to treat four headache attacks acutely with either air or 100% oxygen at 12 L/minute using a nonrebreathing mask. The primary endpoint was freedom from pain at 15 minutes. Secondary endpoints were freedom from pain at 30 minutes; pain reduction at 15, 30, 4…