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In his seminal 1817 monograph, An Essay on the Shaking Palsy, Dr. James Parkinson described the cardinal motor manifestations of his eponymous disease, concluding optimistically that the “senses and intellects” remain “uninjured.” However, neurologists have subsequently learned that cognition is, in fact, frequently affected in Parkinson disease (PD). Now, Williams-Gray and colleagues report on the 5-year cognitive evaluation of 122 patients with incident, early-stage PD but without dementia at baseline (mean age, 69.5; disease duration, 0.2 years).
By 5 years, 17% of the cohort had developed dementia (according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Revision, criteria and Mini-Mental State Examination score). C…