Cholesterol Reduction and the Brain–Heart Connection

A post hoc analysis of SPARCL data provides additional support for the benefits of statin therapy after a stroke or transient ischemic attack, in terms of both brain and cardiac protection.

Researchers previously reported a benefit from 80 mg of atorvastatin daily in preventing recurrent cerebrovascular and cardiovascular events over 5 years after a first stroke or transient ischemic attack (TIA) in the randomized, placebo-controlled, manufacturer-sponsored SPARCL trial (N Engl J Med 2006; 355:549; JW Cardiol Aug 30 2006). Now, the authors report subanalysis results. The 4731 participants had documented elevated LDL levels and stroke or TIA within the prior 6 months and no history or evidence of coronary heart disease (CHD). A handful of randomized patients were not included in the outcomes data for this report.

Rates of major coronary events (MCE) or any CHD endpoint were significantly lower with atorvastatin compared with pla…

Reviewing Author

Steven R. Levine, MD

Cholesterol Reduction and the Brain–Heart Connection

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Reviewing Author