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To study the relation between cerebral amyloid angiopathy (CAA) and cognitive function in elders, researchers performed consecutive autopsies of 404 people in a well-characterized cohort (mean age at death, 86.5). Of this group, 45% had received diagnoses of dementia and 55% had not. The researchers conducted detailed neuropathologic investigations of CAA in multiple brain regions, as well as quantitative assessments of other well-described markers of neurodegenerative disease, including cerebral infarcts, pathologic hallmarks of Alzheimer disease (AD), and Lewy bodies associated with Parkinson spectrum disorders.
Neuropathologic CAA burden was categorized as no-to-minimal, mild-to-moderate, or moderate-to-very severe. Analyses were adjusted…