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Huntington disease (HD) is an autosomal-dominant, progressive degenerative disease characterized by involvement of multiple systems. Treatment remains symptomatic, but trials are under way to find neuroprotective and disease-modifying therapies. At present, medical therapies aimed at decreasing dopaminergic function are the mainstay, with some evidence that drugs with other modes of action, such as NMDA-receptor antagonism, may be useful (Lancet Neurol 2009; 8:844).
To test the efficacy of an investigational dopamine stabilizer, pridopidine, in treating motor symptoms of HD, researchers conducted an manufacturer-funded, 6-month, randomized, double-blind, placebo-controlled trial involving 437 patients with HD. Participants were randomly assi…