Aseptic Meningitis an Adverse Effect of Lamotrigine

An analysis of FDA data suggests that aseptic meningitis may be associated with lamotrigine.

Aseptic meningitis is diagnosed when the cerebrospinal fluid of patients with suspected meningitis contains white blood cells, with negative testing for common bacteria. Drugs that have been associated with aseptic meningitis include nonsteroidal anti-inflammatory drugs, azathioprine, carbamazepine, immunoglobulin, isoniazid, penicillin, and ranitidine.

To investigate a potential association of aseptic meningitis with lamotrigine, researchers conducted a data-mining analysis of cases reported to the U.S. FDA's Adverse Event Reporting System (AERS) database. They searched for reports of aseptic meningitis associated with lamotrigine from December 1994 to November 2009. The investigators looked for more-frequent-than-expected adverse event rep…

Reviewing Author

Jaime Toro, MD

Disclosures

Editorial BoardsMultiple Sclerosis and Related Disorders

Jaime Toro, MD

Disclosures

Editorial BoardsMultiple Sclerosis and Related Disorders