Clinical Spectrum and Serologic Findings in Morvan Syndrome

Morvan syndrome (MoS) is an unusual disease that includes neuromyotonia, autonomic disturbance, insomnia, and encephalopathy. To describe the clinical spectrum of MoS and to localize central nervous system (CNS) antibody binding to voltage-gated potassium channels (VGKC), researchers analyzed findings in 29 patients with probable MoS who were referred to a tertiary center. Referring clinicians confirmed the diagnosis and provided clinical data via questionnaires. To characterize the serum antibodies, the authors used radioimmunoassays, cell-based assays, and mouse brain immunohistochemistry.

VGKC-complex antibodies were present in 79% of the patients at referral; these were mainly directed against LGI1 alone (3 patients), CASPR2 alone (6 pat…