Febrile Status Epilepticus and Hippocampal Sclerosis

Which comes first, FSE or HS? Evidence for both (in different patients) comes from the ongoing FEBSTAT study.

This report from the ongoing Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) study provides the first description of acute imaging findings from a large cohort of children who experienced febrile status epilepticus (FSE). Investigators assessed 191 children aged 1 month to 5 years (median age, 15.7 months) with FSE who underwent magnetic resonance imaging (MRI) at five U.S. sites, most within 1 week after the seizure. Patients with histories of afebrile seizures or evidence of acute central nervous system infection or insult were excluded. Controls were 96 children aged 6 months to 5 years with a first simple febrile seizure; most underwent MRI within 1 week.

The main finding was that 17 case patients (8.9%) had “definite” …

Reviewing Author

Robert C. Knowlton, MD, MSPH

Disclosures

Consultant/Advisory BoardMore Health, Inc.; The Alliance of Medical Companies

Grant/Research SupportNIH Small Business Innovation Research

Leadership Positions in Professional SocietiesSouthern Epilepsy & EEG Society (Treasurer)

Robert C. Knowlton, MD, MSPH

Disclosures

Consultant/Advisory BoardMore Health, Inc.; The Alliance of Medical Companies

Grant/Research SupportNIH Small Business Innovation Research

Leadership Positions in Professional SocietiesSouthern Epilepsy & EEG Society (Treasurer)