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To test the safety and efficacy of low-dose octanoic acid (OA) in treating alcohol-responsive essential tremor (ET), researchers conducted a double-blind, placebo-controlled, crossover study. They recruited 19 patients with confirmed ethanol-responsive ET. The primary outcome was change in accelerometry recording of postural tremor in the dominant hand from baseline to 80 minutes after one 4 mg/kg dose of OA. Secondary outcomes were digital spiral analysis, pharmacokinetic sampling, and safety.
OA had no difference from placebo on the primary outcome. However, OA improved tremor in the dominant hand 300 minutes after administration, and the maximum tremor benefit was seen in both hands at 180 minutes post-administration. Spiral analysis and …