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In an occasional column, Journal Watch Psychiatry editors briefly comment on review articles. These annotations were written by Barbara Geller, MD, Peter Roy-Byrne, MD, and Joel Yager, MD.
Modafinil: Its neurochemical, cognitive, and clinical effects. Modafinil, viewed as a safer but still effective alternative to psychostimulants, is increasingly used off-label for various neuropsychiatric conditions, including ADHD, depression, and schizophrenia. This exhaustive review contains detailed tables of studies involving animals, human volunteers, and psychiatric patients.1 It provides excellent summaries of modafinil’s neurochemical effects (primarily on dopamine and norepinephrine, with secondary effects on glutamate, GABA, orexin, and histamin…