Proline Polymorphisms: Schizophrenia Risk and Brain Function

Researchers use genetic and imaging techniques to investigate the gene encoding for proline oxidase.

In some research studies, hyperprolinemia has been reported as a risk factor for schizophrenia. This is of special interest, because PRODH, the gene that encodes for proline oxidase, is located on chromosome 22q11, and hemizygous deletions of that chromosomal region have been associated with schizophrenia.

To look for associations between PRODH polymorphisms and schizophrenia, researchers genotyped 303 patients with schizophrenia, their parents and unaffected siblings, and 370 normal controls. Two PRODH single nucleotide polymorphisms (SNPs) were found to be protective against schizophrenia; they were significantly more frequent among unaffected siblings than among normal controls. A single SNP and its related haplotype were risk factors for…

Reviewing Author

Barbara Geller, MD

Disclosures

Nothing to disclose

Barbara Geller, MD

Disclosures

Nothing to disclose