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Deficiencies in olfaction have long been associated with schizophrenia and might partly account for some schizophrenia patients’ diminished sensitivity to body odor. Recent research suggests that olfactory abnormalities in schizophrenia might be highly specific and reflect abnormalities in regulation of cyclic adenosine monophosphate (cAMP) in neurons. Typically, when odorants bind to receptors on olfactory neurons in the nasal epithelium, they induce G-protein–mediated activation of adenylyl cyclase, triggering the intracellular cAMP cascade that culminates with firing in olfactory neurons. Researchers examined olfactory acuity to citralva and lyral, two fruity–floral olfactants commonly used in soaps and perfumes, in 30 patients with schi…