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SSRIs are widely prescribed during pregnancy for preexisting SSRI-responsive disorders and for newly developed, severe depressive or anxiety disorders. Information from a large database now raises concerns about gestational hypertension associated with SSRI use in late pregnancy.
Researchers interviewed 5912 mothers of nonmalformed live babies within 6 months of delivery regarding their use of prescribed and over-the-counter preparations starting 2 months before pregnancy and diagnoses of hypertension, preeclampsia, or toxemia during pregnancy. Hypertension was considered gestational if first diagnosed after 20 weeks of pregnancy.
Among 5731 women without pregestational hypertension, 9.4% developed gestational hypertension and 2.7% developed …