Misaligned cycles lead to adverse cardiometabolic consequences in this laboratory study.
We don’t feel right when we change our sleep/wake schedule, whether due to shift work, jet lag, daylight savings time, or illness. Humans have daily behavioral cycles (sleep/wake and fasting/eating) and endogenous circadian cycles (e.g., temperature). These researchers examined the metabolic, autonomic, and endocrine effects of disrupting the alignment between these cycles in 10 adults (5 women).
The participants underwent a multiday protocol in an environment free of time cues. Two 24-hour baseline periods with 8-hour sleep opportunities at subjects’ regular time were followed by seven 28-hour cycles, with sleep and wake periods scheduled in a 1:2 ratio. Subjects received isocaloric meals every 4 hours in wake periods. Exercise was prohibit…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)