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Attempts to predict the best treatment for a patient's depression from genetic variants have been frustrated by the heterogeneity of depression and the multiplicity of relevant factors. These researchers developed a multilocus model of antidepressant response.
First, they analyzed genome-wide association data from a naturalistic depression treatment study in Germany (339 white inpatients; 11% with bipolar illness), its replication (361 white inpatients; 16% with bipolar illness), and the U.S. Systematic Treatment Alternatives to Relieve Depression (STAR*D) study (832 white outpatients). Patients were categorized as early partial responders (scores reduced by ≥25% after 2 weeks of treatment), responders (scores reduced by ≥50% after 5 weeks) …