Loading...
Inflammation produces changes in mood, energy, and behavior, and cytokines might mediate this process. In two articles, researchers report results from a double-blind, crossover, imaging study comparing correlates of the inflammatory response to typhoid vaccine or placebo injection in 16 healthy men.
Levels of plasma interleukin (IL)-6 (but not IL-1RA or tumor necrosis factor α) increased significantly more at 3 hours after typhoid vaccination than after placebo. Participants complained more about confusion, fatigue, and attention problems after vaccination than after placebo, but response times and error rates on cognitive tasks were similar. Maintenance of postvaccine cognitive performance on complicated tasks was associated, on MRI, with …