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Research results suggest that only about 30% of patients treated with a single antidepressant achieve clinical remission and that patients started on two antidepressants have better remission rates than those started on monotherapy. To learn more, investigators initiated an industry-sponsored, randomized, double-blind study involving 105 patients with major depression (Hamilton Rating Scale for Depression [HRSD] score, ≥18).
The study involved four treatment groups: fluoxetine (20 mg/day) plus placebo, mirtazapine (30 mg/day) plus fluoxetine, mirtazapine plus venlafaxine (titrated to 225 mg/day over 14 days), and mirtazapine plus bupropion (150 mg/day). At 6 weeks, all groups showed improvement, with no statistical separation in response rat…