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In a well-replicated finding, auditory sensory gating — the ability to suppress a response in the auditory cortex to the second of two repeated sounds — is deficient in schizophrenia patients and their healthy relatives. In this 4-week study, 39 schizophrenia inpatients, all receiving antipsychotic drugs, were randomly assigned to Cognitive Exercises (CE), a computerized, 6-exercise protocol that emphasizes differentiation of auditory information, or to Cognitive Package (Cogpack), a 64-exercise cognitive training protocol that addresses language and comprehension as well as visuomotor skills, vigilance, memory, logic, and everyday skills.
All patients had poorer auditory sensory gating than 28 healthy controls. In patients, gating improved …