Loss of Brain Volume Predicts the Development of Schizophrenia

Schizophrenia is associated with loss of cerebral volume, especially gray matter loss in frontal and temporal regions. Because this loss is present at the first episode, it is unlikely to be solely a consequence of treatment. Two recent studies examined the timing of these brain changes in populations at high risk for schizophrenia.

In an international study, Mechelli and colleagues conducted clinical evaluations and magnetic resonance imaging (MRI) in 182 clinically well individuals at ultra high risk (UHR) for psychosis (primarily schizophrenia). UHR participants had mild or “attenuated” psychotic symptoms, transient intermittent frank psychotic symptoms, or marked functional decline plus a first-degree relative with a psychotic disorder. …