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Studies have only inconsistently linked cardiovascular anomalies with first-trimester exposure to selective serotonin reuptake inhibitors (SSRIs). The very low base rates of these anomalies require researchers to use large samples to detect statistically significant differences. The current researchers examined the issue in a retrospective study using Finnish national registries.
Data included pregnancies ending in live birth, stillbirth, or termination due to severe fetal anomaly between 1996 and 2006. SSRI exposure was defined as at least one purchase of an SSRI in the month before pregnancy or in the first trimester. SSRI-exposed women were less likely to be married than nonexposed women, twice as likely to smoke or to have a chronic medi…