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Depression and exposure to selective serotonin reuptake inhibitors (SSRIs) during pregnancy have each been linked to adverse fetal and neonatal outcomes. In a population-based study, researchers prospectively examined fetal body and head growth and preterm birth in children of 99 mothers who used SSRIs (1.3% of the study population), 570 (7.4%) with clinically significant depressive symptoms but no SSRI use, and 7027 (91.3%) with no or low depressive symptoms and no SSRI exposure.
SSRI use during pregnancy was determined via self-reports and pharmacy records. Depressive symptoms were assessed with a questionnaire in mid-pregnancy. Fetal head-circumference and body growth was measured by ultrasonography in each trimester. Women in both depres…