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Proteomics, the study of protein function and structure, aims to characterize individual physiology as it changes via numerous environmental influences. More complex than the genome, the proteome varies over time and differs among cells: Distinct cell types express distinct genes; translation from mRNA causes differences in proteins; and many proteins are epigenetically modified after translation through phosphorylation, acetylation, oxidation, histone modification, and other processes.
In this first-ever proteomic study to use shotgun analyses of postmortem tissue from patients with major depressive disorder (MDD), researchers compared samples of dorsolateral prefrontal cortex from 11 patients with MDD plus psychosis, 12 with MDD without ps…