Loading...
Several biological factors are thought to contribute to late-life depression — for example, gray-matter structural changes and cerebrovascular factors that might cause ischemic white-matter lesions at various cortical and subcortical sites. Some of these factors might also affect response to antidepressant treatment. To identify possible predictors of antidepressant response in late-life depression, investigators in this magnetic resonance imaging study examined the relationships among gray-matter regional volumes and thicknesses, severity of white-matter hyperintensities, cognition scores, and clinical outcomes.
Analyses were conducted on 158 nondemented patients with late-life depression who completed 12 weeks' manufacturer-supplied sertra…