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Most pregnant women with bipolar disorder who discontinue mood stabilizers have relapses. Yet, mood stabilizers are associated with an increased risk of malformations. To examine pregnancy and birth outcomes in treated versus untreated bipolar disorder, researchers relied on Swedish health registries.
Analyses adjusted for confounders including demographics, smoking, and substance use disorders. Of 332,137 women who gave birth between 2006 and 2009, 874 had a record of at least two bipolar disorder diagnoses. Compared to women without bipolar disorder, women with the disorder were more likely to smoke, to be overweight, and to have substance use disorders. Bipolar women also had higher rates of induced labor, cesarean or instrumental deliver…