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Prenatal alcohol exposure damages widespread areas in the cortex, hippocampus, and amygdala, among other areas. Some of these pathological features have been attributed to impairments of GABAergic inhibitory systems, possibly involving injury to corticolimbic GABAergic interneurons; dysfunctions in these interneurons have been linked to cognitive and social-behavioral disruptions. To explore whether stem-cell regenerative therapy might benefit human fetal alcohol syndrome (FAS), investigators used an animal FAS model, in which pregnant rats were intragastrically fed alcohol at critical periods and later allowed to deliver and nurse their offspring.
Compared with non-FAS rats, FAS rats showed impairments in memory, cognitive behavior, and soc…