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Identifying genetic profiles associated with success in smoking cessation and overlapping with genetic profiles indicating addiction potential has been problematic. Genome-wide association studies have found huge numbers of risk alleles, each with relatively small effects. To overcome this problem, investigators (who have a patent application) developed a mathematical model using 12,058 single nucleotide polymorphisms (SNPs; Mol Med 2010; 16:247) and, in this partly industry-funded study, tested this score in three investigations.
One study involved a placebo-controlled, double-blind, randomized trial of nicotine replacement therapy (NRT). Participants without precessation signs of quit success were re-randomized to NRT maintenance, add-on b…