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In patients with serious mental illness, little physical activity, poor diet, and adverse metabolic consequences of many atypical antipsychotic and other psychiatric medications contribute to high rates of obesity and mortality — patients' obesity rates are nearly twice as high and mortality rates are two to more than three times as high as in the general population. These investigators randomized 291 patients with schizophrenia-related conditions, bipolar disorder, or major depression (but no active alcohol or other substance abuse) from 10 psychiatric rehabilitation centers to a lifestyle intervention group or to a control group (mean age, 45; 50% male; 38% black; mean baseline weight, 226 lb.; mean body-mass index, 36.3).
The rehabilitati…