Obesity-Related Glomerulopathy

Isolated case reports and results of small series suggest the existence of obesity-related glomerulopathy (ORG), a condition unfamiliar to most clinicians. Researchers from Columbia University . . .

Isolated case reports and results of small series suggest the existence of obesity-related glomerulopathy (ORG), a condition unfamiliar to most clinicians. Researchers from Columbia University present what they call the "first large renal-biopsy-based clinicopathological study" of ORG.

ORG was defined as glomerulomegaly (glomerular enlargement) in a person with a body-mass index higher than 30 kg/m². During the past 14 years, 103 cases of ORG were diagnosed from 6818 renal biopsies submitted to the pathology laboratory; adequate clinical information was available for 71 patients (mean age, 43 years; mean BMI, 41.7 kg/m²). Of these, 14 patients had glomerulomegaly alone, and 57 had glomerulomegaly plus focal segmental glomerulosclerosis (FSGS…

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AS Brett