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In the past decade, researchers have discovered a group of genes that affects life span in many species, from yeast to mammals. Certain stressors, such as caloric restriction, extend life span through their effect on the activity of these "aging genes" (Journal Watch Aug 27 2002 ). Investigators at Harvard have identified a new molecular pathway that influences life span in yeast.
Research has shown that increased activity of a particular yeast gene, SIR2, leads to longer life span. In a series of new studies, the investigators found that a protein called pyrazinamidase/nicotinamidase 1, which is encoded by PNC1, directly affects SIR2. Specifically, increased activity of PNC1 decreases levels of intracellular nicotinamide, thereby increasing…