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In 3 studies from the Women's Health Initiative (WHI), researchers examined the effects of hormone therapy (HT) on central nervous system function in postmenopausal women who were randomized to receive daily conjugated estrogen (0.625 mg) plus medroxyprogesterone acetate (2.5 mg) or placebo. The WHI estrogen-progestin arm was stopped prematurely in 2002 because overall risks of HT outweighed benefits (Journal Watch Jul 26 2002).
In the WHI Memory Study (WHIMS), 4532 women (age, ≥65) were tested annually with the Modified Mini-Mental State Examination (3MSE). Probable dementia was diagnosed in 40 women who received HT and in 21 women on placebo (hazard ratio, 2.05) after an average of 4 years of follow-up; diagnoses of mild cognitive impairme…